Stephen C. Cannon, MD, PhD is a Professor in the Department of Physiology in the David Geffen School of Medicine at UCLA. He received both a B.S and an M.S. in Mechanical Engineering at Washington University in St. Louis in 1980. His master’s thesis explored how increased muscle stiffness and intensity of the stretch reflex with mechanical loading produces an instability that may cause tremor. Upon graduation, he entered the Medical Scientists Training Program at Johns Hopkins where he worked with Prof. David Robinson to identify the locus of the brainstem neural integrator for the oculomotor system and demonstrated how lateral inhibition is a critical neural network feature of this premotor circuit. He completed a medical internship and neurology residency at Massachusetts Hospital, where he was chief resident in 1990. Dr. Cannon then completed a research postdoctoral fellowship in David Corey’s lab, where he made a fundamental discovery of the sodium channel defect that causes susceptibility to periodic paralysis. Based on this new work on channelopathies of muscle, he started a lab in the neurobiology department at Harvard Medical School where he was on the faculty until 2002 when he moved to UT Southwestern Medical Center in Dallas as Chair of Neurology. In 2010, he became Associate Dean for Undergraduate Medical Education and developed a combined BA/MD training program with UT Dallas. In 2015, Dr. Cannon was recruited to UCLA as the Chair of Physiology in the David Geffen School of Medicine.

Research Interests: Ion channelopathies of skeletal muscle

  • Ph.D. in Biomedical Engineering
    • Johns Hopkins School of Medicine, Baltimore, 1986
  • M.D.
    • Johns Hopkins School of Medicine, Baltimore, 1986
  • M.S. in Mechanical Engineering
    • Washington University, St. Louis, 1980
  • B.S. in Mechanical Engineering
    • Washington University, St. Louis, 1980

 

  • Potassium-sensitive loss of muscle force in the setting of reduced inward rectifier K+ current: Implications for Andersen-Tawil syndrome. Proc Natl Acad Sci U S A. 2025 Apr; 122(13):e2418021122.Elia N, Quiñonez M, Wu F, Mokhonova E, DiFranco M, Spencer MJ, Cannon SC.  PMID: 40138348; PMCID: PMC12002197.
  • Periodic paralysis. Handb Clin Neurol. 2024; 203:39-58.Cannon SC.  PMID: 39174253; PMCID: PMC11556526.
  • Retigabine suppresses loss of force in mouse models of hypokalaemic periodic paralysis. Brain. 2023 04 19; 146(4):1554-1560.Quiñonez M, DiFranco M, Wu F, Cannon SC.  PMID: 36718088; PMCID: PMC10115351.
  • Voltage-dependent Ca2+ release is impaired in hypokalemic periodic paralysis caused by CaV1. -R528H but not by NaV1.4-R669H. Am J Physiol Cell Physiol. 2022 08 01; 323(2):C478-C485.DiFranco M, Cannon SC.  PMID: 35759432; PMCID: PMC9359662.
  • The distinct role of the four voltage sensors of the skeletal CaV1.  channel in voltage-dependent activation. J Gen Physiol. 2021 11 01; 153(11).Savalli N, Angelini M, Steccanella F, Wier J, Wu F, Quinonez M, DiFranco M, Neely A, Cannon SC, Olcese R.  PMID: 34546289; PMCID: PMC8460119.
  • Gating pore currents occur in CaV1.  domain III mutants associated with HypoPP. J Gen Physiol. 2021 11 01; 153(11).Wu F, Quinonez M, Cannon SC.  PMID: 34463712; PMCID: PMC8563280.
  • 2022 Biophysical Society Award in the Biophysics of Health and Disease
  • 2019 Paul Horowicz Endowed Lecture - Univ Rochester
  • 2014 Regents Outstanding Teaching Award, University of Texas
  • 2012 Patricia A. Smith Distinguished Chair in Neuromuscular Disease, UT Southwestern
  • 2009 MERIT Award, NIH
  • 2002 Linda and Mitch Hart Distinguished Chair in Neurology
  • 2000 Derek Denny-Brown Neurological Scholar Award, American Academy of Neurology
  • 1995 Esther and Joseph Klingenstein Fellowship
  • 1992 Alfred P. Sloan Fellowship
  • 1991 HHMI Postdoctoral Fellowship for Physicians
  • 1990 Charles A Dana Fellowship
  • 1990 Chief Resident in Neurology, Massachusetts General Hospital
  • 1984 Michael A Shanoff Award, Johns Hopkins School of Medicine
  • 1980 summa cum laude, B.S. Mechanical Engineering Washington University
  • 1976 Alexander S. Langsdorf Fellowship, Washington University (St. Louis)